Enfermedad de Mondor y mamoplastías / Mondor's disease and mammoplasty

Resumen Objetivo: Revisar la incidencia de esta enfermedad en pacientes sometidos a mamoplastías en una clínicaprivada en el período de 11 años, con el fin de describir sus síntomas y signos, diagnóstico, tratamiento y evolución. Materiales y Método: Se estudiaron 355 mujeres que se sometieron a mamoplastías estéticas. Se excluyó aquellas cirugías reconstructivas secundarias a cáncer de mama y aquellas con otros antecedentes oncológicos previos. La información fue recolectada de las fichas clínicas. Resultado: Se analizan 710 mamas operadas en el período 2008-2018, de las cuales seis mamas (6/710) evolucionaron con enfermedad de Mondor (0,8%). El diagnóstico se realizó clínicamente. Todos los casos recibieron terapia antiinflamatoria oral y local, respondiendo favorablemente. Discusión: Existe poca literatura publicada al respecto. Casos bilaterales son menos reportados. Pareciera asociarse con cirugías del surco submamario y no está claro que requiera curación terapéutica. Conclusiones: La enfermedad de Mondor es infrecuente, puede presentarse secundario a mamoplastías, es de diagnóstico clínico y sólo tratamiento sintomático con evolución satisfactoria sin secuelas.

Aim: Review the disease incidence in patients who had mammoplasties in a private clinic on a 11 year-period. The purpose is to describe their symptoms and signs, diagnosis, treatment and evolution. Materials and Method: 355 women who underwent cosmetic mammoplasties were studied. Those reconstructive surgeries secondary to breast cancer and those with other previous oncological history were excluded. The information was collected from clinical files. Results: 710 breasts operated between 2008-2018 are analyzed, six of them (6/710) evolved Mondor disease (0.8%). The diagnosis was made clinically. All cases received oral and local antiinflammatory therapy, responding favorably. Discussion: There is a few published literature about it. Bilateral cases are less reported. It appears to be associated with surgeries of the submammary sulcus and it is not clear that it requires therapeutic cure. Conclusions: Mondor's disease is infrequent, can occur secondary to mammoplasty, diagnosis is clinical, treatment is symptomatic, all cases had satisfactory evolution without sequelae.

Flebectasia yeyunal como causa de hemorragia digestiva media masiva / Jejunal phlebectasia as a cause of massive gastrointestinal hemorrhage

Las anormalidades vasculares del tracto gastrointestinal son una causa común de sangrado digestivo. La mayoría se localizan al alcance de la endoscopía digestiva alta y/o colonoscopía, una vez descartado ello, obliga a considerar al intestino delgado como causa de la hemorragia. El manejo exitoso de una hemorragia digestiva depende principalmente de la localización oportuna de la fuente del sangrado, sin embargo esta tarea puede ser difícil, cuando la causa no está al alcance de los métodos convencionales. Presentamos el caso de un paciente varón de 21 años cuyo diagnóstico fue una flebectasia yeyunal sangrante, luego de una cuidadosa evaluación de los hallazgos de la cápsula endoscópica y laparoscopía.

Vascular abnormalities of the gastrointestinal tract are a common cause of gastrointestinal bleeding. Most of them are located within the reach of the upper endoscopy or colonoscopy, although once discarded, it forces to consider small bowel as the source of bleeding. The successful management of a gastrointestinal bleeding depends mainly on the timely location of the source of bleeding. Nevertheless this task can be difficult when the cause is not within the reach of conventional methods. We present a case of a 21 year-old men in which the diagnosis of bleeding yeyunal phlebectasia was made by the findings of the capsule endoscopy and laparoscopy.

Clinical Outcomes of Cryopreserved Arterial Allograft Used as a Vascular Conduit for Hemodialysis

This single center cohort study aimed to test the hypothesis that use of a cryopreserved arterial allograft could avoid the maturation or healing process of a new vascular access and to evaluate the patency of this technique compared with that of vascular access using a prosthetic graft. Between April 2012 and March 2013, 20 patients underwent an upper arm vascular access using a cryopreserved arterial allograft for failed or failing vascular accesses and 53 using a prosthetic graft were included in this study. The mean duration of catheter dependence, calculated as the time interval from upper arm access placement to removal of the tunneled central catheter after successful cannulation of the access, was significantly longer for accesses using a prosthetic graft than a cryopreserved arterial allograft (34.4 ± 11.39 days vs. 4.9 ± 8.5 days, P < 0.001). In the allograft group, use of vascular access started within 7 days in 16 patients (80%), as soon as from the day of surgery in 10 patients. Primary (unassisted; P = 0.314) and cumulative (assisted; P = 0.673) access survivals were similar in the two groups. There were no postoperative complications related to the use of a cryopreserved iliac arterial allograft except for one patient who experienced wound hematoma. In conclusion, upper arm vascular access using a cryopreserved arterial allograft may permit immediate hemodialysis without the maturation or healing process, resulting in access survival comparable to that of an access using a prosthetic graft.

Clinical Outcomes of Cryopreserved Arterial Allograft Used as a Vascular Conduit for Hemodialysis

This single center cohort study aimed to test the hypothesis that use of a cryopreserved arterial allograft could avoid the maturation or healing process of a new vascular access and to evaluate the patency of this technique compared with that of vascular access using a prosthetic graft. Between April 2012 and March 2013, 20 patients underwent an upper arm vascular access using a cryopreserved arterial allograft for failed or failing vascular accesses and 53 using a prosthetic graft were included in this study. The mean duration of catheter dependence, calculated as the time interval from upper arm access placement to removal of the tunneled central catheter after successful cannulation of the access, was significantly longer for accesses using a prosthetic graft than a cryopreserved arterial allograft (34.4 ± 11.39 days vs. 4.9 ± 8.5 days, P < 0.001). In the allograft group, use of vascular access started within 7 days in 16 patients (80%), as soon as from the day of surgery in 10 patients. Primary (unassisted; P = 0.314) and cumulative (assisted; P = 0.673) access survivals were similar in the two groups. There were no postoperative complications related to the use of a cryopreserved iliac arterial allograft except for one patient who experienced wound hematoma. In conclusion, upper arm vascular access using a cryopreserved arterial allograft may permit immediate hemodialysis without the maturation or healing process, resulting in access survival comparable to that of an access using a prosthetic graft.

Increased incidence of abnormal reflux flow in lower extremity veins of cirrhotic patients by doppler ultrasonography

To determine incidence of abnormal reflux flow [ARF] in legs of cirrhotic patients by Doppler ultrasonography [DUS]. We prospectively studied 100 patients and 56 controls from the Faculty of Medicine, Eskisehir Osmangazi University Eskisehir, Turkey, between January 2010 and December 2011. We classified the legs according to the Clinical Etiology Anatomy Pathophysiology [CEAP] scores. Lower extremity superficial and deep veins were examined in supine position by DUS for ARF. Reflux flows more than 1000 msec were considered as abnormal. Abnormal reflux flow was classified in 3 categories as superficial [SARF], deep [DARF], and SARF and/or DARF [ARF]. We also performed abdominal DUS to depict anterior abdominal collateral and paraumbilical vein. Statistical analysis was carried out by using analysis of variance with Tukey test, t-test, and correlation coefficient analysis. Percentages of SARF in patients were 56%, DARF 52%, and ARF 58%. Correlation analysis showed association between SARF or DARF or ARF and cirrhosis [p=0.002, p=0.000, p=0.001]. Patients were distributed within CEAP 1 to CEAP 4. There was an association between SARF or DARF and CEAP 1 [p=0.007, p=0.000] or CEAP 2 [p=0.004, p=0.041] or CEAP 4 [p=0.022, p=0.90]. We showed no correlation between CEAP 3 and SARF or DARF. There were also correlation between paraumbilical vein and SARF [p=0.015]. Cirrhotic patients increased incidence of ARF at lower extremity veins and CEAP classification creates and provides essential information

Un caso de síndrome de Adams-Oliver con venas congénitas, dilatadas y persistentes en el cuero cabelludo / A case of Adams-Oliver syndrome with congenital and persistent dilated veins in the scalp

El síndrome de Adams-Oliver es un desorden congénito raro, caracterizado por la presencia de aplasia cutis congénita y defectos terminales transversos de los miembros. Comunicamos el caso de una niña de 4 años de edad con síndrome de Adams-Oliver que presenta venas congénitas, tortuosas y dilatadas en el cuero cabelludo, aplasia cutis congénita con defectos parciales del hueso craneal subyacente, calcificaciones intracraneales y anomalías leves de los pies.

Adams-Oliver syndrome is a rare congenital disorder characterized by aplasia cutis congenita and terminal transverse limb defects. We report a case of a 4-year-old girl with Adams-Oliver syndrome with congenital dilated and tortuous scalp veins, aplasia cutis congenita with partial underlying skull defects, intracranial calcifications, and mild foot anomalies.

CT cavernosography: a new method for evaluating venous incompetence in impotent patients

Cavernosography is traditionally recognized as an imaging modality for evaluation of venous leakage in impotent men. We introduce CT cavernosography as a novel method for demonstrating leaking veins. Sixty-seven patients diagnosed as venous incompetence by Doppler study, and eight normal subjects were enrolled into the study. After intracavernosal injection of papaverine, normal saline was injected into the corpora cavernosa and the injection rate was gradually increased and the penis was observed to obtain the injection rate causing erection. Then contrast media was injected into the corpus cavernosum with obtained injection rate followed by CT scan of the penis and pelvis. In the first group, 63 patients [94%] had venous leakage by CT cavernosography. In this group, full erection was observed at the rate of 36 ml/min of saline injection in three patients and 24 ml/min in one patient. In 46 patients [73%], erection was induced with saline injection at the rates of 48-120 ml/min, and in 17 patients [27%] no full erection was demonstrated even at the injection rate of 120 ml/min. In the 2nd group we observed full erection after saline injection at the rates of 36 ml/min and 24 ml/min in five and three patients, respectively. Beside the capability of CT source images in precise visualization of all leaking veins without superimposition of bony structures, different techniques of two- or three- dimensional reformation enable us to demonstrate the anatomy of the penis and the leaking veins elegantly for further surgical planning

Termination of the facial vein into the external jugular vein: an anatomical variation / Terminação da veia facial na veia jugular externa: uma variação anatômica

Different patterns of variations in the venous drainage have been observed in the past. During routine dissection in our Department of Anatomy, an unusual drainage pattern of the veins of the left side of the face of a middle aged cadaver was observed. The facial vein presented a normal course from its origin up to the base of mandible, and then it crossed the base of mandible posteriorly to the facial artery. Thereafter, it joined with the anterior division of retromandibular vein to form the common facial vein, which drained into the external jugular vein directly. Sound anatomic knowledge of the above variation in facial veins is essential to the success of surgical procedures in this region.

Padrões distintos de variações na drenagem venosa já foram observados. Durante a dissecção de rotina em nosso Departamento de Anatomia, observou-se um padrão incomum de drenagem das veias do lado esquerdo da face de um cadáver de meia idade. A veia facial apresentava curso normal de sua origem até a base da mandíbula, e então atravessava a base da mandíbula posteriormente à artéria facial. A seguir, juntava-se à divisão anterior da veia retromandibular para formar a veia facial comum, que drenava diretamente para a veia jugular externa. Um bom conhecimento anatômico da variação descrita acima nas veias faciais é essencial para garantir o sucesso que procedimentos cirúrgicos nessa região.

Estudo anatômico das válvulas do tronco gastrocnêmio em cadáveres humanos / Anatomical study of valves in the gastrocnemius trunk in human cadavers

CONTEXTO: As válvulas são estruturas características das veias, importantes na orientação do fluxo sangüíneo. Sua presença no sistema venoso superficial dos membros inferiores tem sido bastante estudada. No entanto, nas veias profundas, como a veia gastrocnêmia, a literatura é escassa. OBJETIVO: Realizar um estudo anatômico das válvulas do tronco gastrocnêmio principal em cadáveres humanos adultos. MÉTODOS: Foram dissecados os troncos gastrocnêmios principais de 80 cabeças de músculos gastrocnêmios de 20 cadáveres adultos do sexo masculino, com idade entre 40 e 68 anos, após fixados e mantidos em solução de formol a 10 por cento. Os troncos e tipos de redes foram classificados de acordo com o proposto por Aragão et al. As válvulas foram estudadas quanto ao número, distribuição, localização e tipo com relação ao tronco, perna, cabeça do músculo e tipo de rede gastrocnêmia. RESULTADO: Em 80 cabeças de músculos gastrocnêmios, foram encontrados 95 troncos gastrocnêmios principais, sendo que 17 deles eram duplicados. Foram encontradas 65 válvulas em 60 troncos gastrocnêmios principais, todas elas do tipo bicúspide, sendo 35 na rede tipo I, 23 na do tipo II e sete na rede tipo III. Em 74 por cento dos casos, as válvulas estavam localizadas no terço proximal do tronco gastrocnêmio principal. CONCLUSÃO: As válvulas foram encontradas em todos os tipos de redes que possuíam tronco gastrocnêmio principal, eram todas do tipo bicúspide e se localizaram predominantemente no terço proximal dos troncos gastrocnêmios principais.

BACKGROUND: Valves are characteristic structures of veins and are important to guide blood flow. Their presence in the superficial venous system of lower limbs has been well studied. However, there is a lack of published literature on deep veins, such as the gastrocnemius vein. OBJECTIVE: To carry out an anatomical study of the veins in the main gastrocnemius trunk in adult human cadavers. METHODS: The main gastrocnemius trunks of 80 gastrocnemius muscle heads of 20 adult cadavers were dissected. The cadavers were males, aged between 40 and 68 years, and fixed in 10 percent formaldehyde solution. Trunks and net types were classified according to Aragão et al.'s proposal. The valves were studied as to quantity, distribution, location and type with regard to trunk, leg, muscle head and type of gastrocnemius net. RESULTS: Of 80 gastrocnemius muscle heads, there were 95 main gastrocnemius trunks, and 17 were duplicated. There were 65 valves in 60 gastrocnemius trunks, all of them bicuspid: 35 in type I net, 23 in type II and seven in type III net. Valves were located in the proximal third of the main gastrocnemius trunk in 74 percent of cases. CONCLUSION: Valves were found in all net types that had main gastrocnemius trunk. These valves were bicuspid and predominantly located in the proximal third of main gastrocnemius trunks.

Histological characteristics of arterialized medullary vein in spinal dural arteriovenous fistulas related with clinical findings: report of five cases.

The histological features of arterialized medullary vein (MV) in spinal dural arteriovenous fistulas (SDAVF) were studied in five consecutive patients who presented with progressive congestive myelopathy. Retrograde venous filling on preoperative angiography was recognized as being severe in 3 cases and moderate in 2 cases. Direct intradural interruption of the arterialized MV was performed in all patients. The arterialized MV was sampled and examined histologically to determine the percentage of the hyperplasia of venous wall (hypertrophic ratio). Histological examination of arterialized MV showed that hypertrophic alteration of venous wall structure was due to hyperplasia of elastic fibers, ranging from 41 to 82%. Patients with angiographically severe venous hypertension tended to have a higher hypertrophic ratio than patients with moderate venous hypertension. Our observations support the clinical concept that long-standing arterial stress in the spinal venous circulation causes histological alterations of spinal vascular structure associated with the progression of venous hypertension. We suggested that possibly the histological parameter can be used for predicting neurological recovery after occlusion of the fistulas.

Anatomia das veias e troncos gastrocnêmios em cadáveres humanos adultos / The anatomy of the gastrocnemial veins and trunks in adults human cadavers

Objetivo: realizar, através de dissecção, um estudo anatômico das veias gastrocnêmias em cadáveres humanos adultos.Métodos: foram dissecadas 80 cabeças de músculo gastrocnêmio em 20 cadáveres do sexo masculino, fixados e mantidos em uma solução de formol a 10 por cento. Todas as veias gastrocnêmias foram dissecadas desde a emergência das cabeças do músculo gastrocnêmio até o seulocal de desembocadura. Para a tomada das medidas, foi utilizado um paquímetro digital. Foram obtidas estatísticas descritivas para as variáveis do estudo.Resultados: em 80 cabeças de músculos gastrocnêmios dissecadas, foram encontradas 438 veias gastrocnêmias, sendo 233 na perna direita e 205 na perna esquerda. Foram identificados 95 troncos gastrocnêmios principais, 51 na perna direita e 44 na esquerda. A extensão dos troncos variou de 0,5 cm a 7,8 cm, com uma amplitude expressiva no conjunto das observações de 7,3 cm. Do total de troncosgastrocnêmios principais, 83 desembocavam na veia poplítea e 12, em outras veias.Conclusão: a quantidade de veias e troncos gastrocnêmios foi maior na perna direita, e a extensão média do tronco gastrocnêmio principalfoi semelhante em ambas às pernas. A maioria desses troncos desembocava na veia poplítea.

Management of primary venous aneurysms

Venous aneurysms are a relatively rare abnormality. Unlike arterial aneurysms, venous aneurysms are a much less frequent abnormality. The purpose of our study was to review our experience in the management of venous aneurysms. Nine patients with venous aneurysms, who had undergone operation in the Department of Cardiovascular Surgery, Yuzuncu Yil University Medical School, Van, Turkey, during the period September 1997 through to May 2003, were included in this study. There were 5 female and 4 male patients, ranging in age from 16-47-years with a mean age of 31 +/- 7 years. They were diagnosed by color flow duplex imaging. Eight patients had saccular aneurysm; the remaining one patient with basilar vein aneurysm, had fusiform aneurysm. Aneurysms were located the lower extremities in 4 cases, the upper extremity in 4, and external jugular vein in one. Aneurysms size ranged from 2, 3 to 5, 5 cm [mean 3, 6 cm]. There were no symptoms in 2 patients [cephalic vein aneurysm in one patient, short saphenous vein aneurysm in one]. These patients were operated on for cosmetic purposes. Six patients complained of pain associated with a subcutaneous swelling. The remaining one patient with popliteal vein aneurysm complained of extremity pain, associated with deep venous thrombosis. All patients underwent surgery under local anesthesia. In 7 patients, aneurysms were resected and venous continuity with a graft was found unnecessary. End to end anastomosis was performed in 2 patients [popliteal vein aneurysm in one and axillary vein aneurysm in one]. During follow up period, there were no recurrences. Venous aneurysms may cause thrombophlebitis, thrombus formation, pulmonary embolism and theoretical complication of spontaneous rupture. Varicose veins, hemangiomas, lymphocele, hernias, hygromas, arteriovenous fistulas and similar subcutaneous swellings located subcutaneous venous spaces should be considered in the differential diagnosis. Consequently, we suggest that surgical treatment be performed to prevent subsequent complications in all cases

Malignant fibrous histiocytoma: Vascular invasion and metastasis to heart

A 52 years old male fisherman presented in April 2000, with a history of pain in the left calf while standing and walking with swelling of the ipsilateral foot for the last three months. Clinically he was an overweight, middle aged man. His pulse, blood pressure and respiratory rate were normal. There were no significant findings on the examination of chest and abdomen. Local examination revealed pitting edema along with increased circumference of the left leg and lower thigh. The superficial veins were prominent on the left side. Inguinal lymph nodes were not enlarged. On dorsiflexion of the left foot, pain was experienced in the left calf. His routine investigations were within normal limits. However, Doppler ultrasound reported thrombosis of the left femoral vein. The clot extended from the sub sartorial canal to the upper part of femoral triangle. He was diagnosed as a case of deep vein thrombosis and treated with anticoagulants, stockinnette and analgesics. There was symptomatic improvement in the calf pain and the edema decreased. Three months later he started complaining of vague pain in the anteromedial aspect of the left thigh. On examination an ill-defined, diffuse, firm lump could be felt in the femoral triangle. MRI of the area exhibited a soft tissue mass of 10 x 6 cm size arising from the deep soft tissues of the femoral triangle, 16 surrounding the femoral vessels and infiltrating into the adjoining muscles. Biopsy showed grade IV malignant pleomorphic fibrous histiocytoma. During surgery [wide margin resection planned] femoral vein was solidified and filled with the tumor mass which was extending above the inguinal ligament. The femoral artery was also surrounded by the tumor mass which resulted in iatrogenic injury during dissection, that was immediately repaired. Only debulking was done due to inoperability of the tumour. During the next six weeks, the patient developed a fungating mass in the left femoral triangle culminating in fatal arterial bleeding

Aspectos microscópicos do fígado de ratos após administração do óleo de copaíba / Microscopic aspects of the rats liver after copaiba oil administration

A utilização de plantas medicinais é uma prática comumente observada nos países em desenvolvimento. Desta forma objetivou-se verificar os efeitos microscópicos do óleo de copaíba no fígado de ratos. Para tal foram utilizados 50 Rattus norvegicus albinus, machos, distribuídos em cinco grupos: Grupo Copaíba 0,63 (GC0,63 ml/Kg de óleo de copaíba), Grupo copaíba 0,06 (GC0,06 ml/Kg de óleo de copaíba), Grupo Água (GA0,63 ml/kg de água), Grupo milho (GM0,63 ml/Kg de óleo de milho) e grupo Padrão (GP). As substâncias foram administradas diariamente por 14 dias, quando os animais foram submetidos à eutanásia. Os resultados obtidos demonstraram que microscopicamente, não foram encontradas alterações hepatocelulares, porém, foi verificado congestão vascular nas veias portais e centrolobulares, maior no grupo GC0,63 em relação aos grupos GC0,06, GM, GA e GP (<0,05). Já no grupo GC0,06, apesar de não haver diferença estatística, foi observado congestão em maior intensidade que nos grupos GM, GA e GP (p>0,05) o que sugere haver uma relação dose dependente. Os autores concluem que, de acordo com a metodologia empregada, o óleo de copaíba tanto na dose de 0,06 ml/kg como de 0,63 ml/kg foi capaz de promover congestão vascular no fígado de ratos, sugerindo ação dose dependente.

Pulmonary arterio-venous fistula associated with deep vein tortuosity

A right to left pulmonary arterio-venous fistula was suspected clinically in a 21-year-old cyanotic male and confirmed by angiography and contrast echo-cardiography. An associated deep vein tortuosity of the lower extremity was documented by contrast venography

Vascular morphology in testes of infertile males with varicocele.

Testicular biopsies of 38 infertile males with varicocele were examined for vascular changes. Endothelial prominence, intimal fibrosis and increased amount of collagen in the media were present in veins, venules and capillaries. The small vessels were thickened with the deposition of homogeneous bluish pink material. The material stained green on Van Geison stain. The vascular changes were bilateral even in patients of unilateral varicocele. The severity of these changes was not related to tubular morphology.